# Limitations of measurement-based system functions in magnetic particle imaging

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[唯一标识符]:CDSTIC.SPIE.10.1117/12.844181

[文献来源]:国际光学工程学会数据库

[文献类型]:科技会议

[标题]:Limitations of measurement-based system functions in magnetic particle imaging

[作者]:T. Knopp;T. F. Sattel;S. Biederer;T. M. Buzug;;Univ. zu L?beck (Germany)

[文摘]:Magnetic particle imaging (MPI) is a new tomographic imaging technique capable of determining the spatialdistribution of superparamagnetic iron oxide particles at high temporal and spatial resolution. Reconstructionof the particle distribution requires the system function to be known. In almost all other tomographic imagingtechniques, a basic mathematical model of the system function exists, so that for reconstruction of an image,only measured data from the object under examination have to be provided. Due to the complex behavior ofthe particle dynamics, this is more complicated in MPI. Therefore, to date, the system function is measured in atedious calibration procedure. To this end, a small delta sample is moved to each position inside the measuringfield, while the magnetization response is acquired consecutively. However, although this measurement-basedapproach provides a good estimate of the system function, it has several drawbacks. Most important, themeasured system function contains noise, which limits the size of the delta sample and in turn the resolutionof the sampling grid. In this work, the noise induced limitations of the measurement-based system function areinvestigated in a simulation study. More precisely, the influence of the system function noise and the size of thedelta sample on the resulting image quality after reconstruction are analyzed.

[卷]:7626

[会议名称]:Medical Imaging 2010: Biomedical Applications in Molecular, Structural, and Functional Imaging

[会议时间]:Sunday 14 February 2010

[会议信息]:San Diego, California, United States

[馆藏索取号]:10.1117/12.844181

[总页数]:8

[文献来源]:国际光学工程学会数据库

[文献类型]:科技会议

[标题]:Limitations of measurement-based system functions in magnetic particle imaging

[作者]:T. Knopp;T. F. Sattel;S. Biederer;T. M. Buzug;;Univ. zu L?beck (Germany)

[文摘]:Magnetic particle imaging (MPI) is a new tomographic imaging technique capable of determining the spatialdistribution of superparamagnetic iron oxide particles at high temporal and spatial resolution. Reconstructionof the particle distribution requires the system function to be known. In almost all other tomographic imagingtechniques, a basic mathematical model of the system function exists, so that for reconstruction of an image,only measured data from the object under examination have to be provided. Due to the complex behavior ofthe particle dynamics, this is more complicated in MPI. Therefore, to date, the system function is measured in atedious calibration procedure. To this end, a small delta sample is moved to each position inside the measuringfield, while the magnetization response is acquired consecutively. However, although this measurement-basedapproach provides a good estimate of the system function, it has several drawbacks. Most important, themeasured system function contains noise, which limits the size of the delta sample and in turn the resolutionof the sampling grid. In this work, the noise induced limitations of the measurement-based system function areinvestigated in a simulation study. More precisely, the influence of the system function noise and the size of thedelta sample on the resulting image quality after reconstruction are analyzed.

[卷]:7626

[会议名称]:Medical Imaging 2010: Biomedical Applications in Molecular, Structural, and Functional Imaging

[会议时间]:Sunday 14 February 2010

[会议信息]:San Diego, California, United States

[馆藏索取号]:10.1117/12.844181

[总页数]:8

**下载地址:**点击此处下载